SCHEMBL28430747

SCHEMBL28430747

O=c1c2cc(C(F)(F)F)ccc2c2ccccc2n1-c1cccc2cccnc12

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45
GAA P10253 1/20 0.45
HPGD P15428 1/20 0.45
CYP2C19 P33261 1/20 0.45
MAT2A P31153 4/20 0.42
ALDH1A1 P00352 2/20 0.40
KIF11 P52732 2/20 0.40
MAPT P10636 1/20 0.39
SLC40A1 Q9NP59 4/20 0.39
EGLN1 Q9GZT9 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
HSP90AA1 P07900 1/20 0.38
CCNB2 O95067 1/20 0.37
CDK1 P06493 1/20 0.37
CCNB1 P14635 1/20 0.37
GSK3B P49841 1/20 0.37
CDK5 Q00535 1/20 0.37
CDK5R1 Q15078 1/20 0.37
CCNB3 Q8WWL7 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28426493 0.96 CYP1A2 (0.47) CYP1A2CYP3A4GAAHPGDCYP2C19
SCHEMBL28429237 0.85 CYP1A2 (0.59) CYP1A2CYP3A4GAAHPGDCYP2C19
SCHEMBL21636036 0.83 CYP2C19 (0.47) CYP1A2CYP3A4GAAHPGDCYP2C19
SCHEMBL21636034 0.83 CYP1A2 (0.47) CYP1A2CYP3A4GAAHPGDCYP2C19
SCHEMBL26045874 0.83 GAA (0.47) CYP1A2CYP3A4GAAHPGDCYP2C19
SCHEMBL28426491 0.83 CYP1A2 (0.47) CYP1A2CYP3A4GAAHPGDCYP2C19
SCHEMBL28436842 0.81 CYP1A2 (0.50) CYP1A2CYP3A4GAAHPGDCYP2C19
SCHEMBL28432293 0.80 CYP1A2 (0.45) CYP1A2CYP3A4GAAHPGDCYP2C19
SCHEMBL21636033 0.79 CYP1A2 (0.50) CYP1A2CYP3A4GAAHPGDCYP2C19
SCHEMBL28437664 0.79 CYP1A2 (0.50) CYP1A2CYP3A4GAAHPGDCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109320497-B Method for preparing phenanthridinone compound by copper compound induction 广州大学 2020-07-31 CN disclosed