Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 12/20 | 0.85 |
| ▸ | MET | P08581 | 1/20 | 0.58 |
| ▸ | FLT3 | P36888 | 2/20 | 0.57 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.51 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28436289 | 0.92 | ALK (1.00) | ALKMETFLT3PTK2GLO1 | |
| SCHEMBL28430786 | 0.90 | ALK (0.87) | ALKMETFLT3PTK2GLO1 | |
| SCHEMBL28438028 | 0.89 | ALK (0.78) | ALKMETFLT3PTK2GLO1 | |
| SCHEMBL28435838 | 0.88 | ALK (0.88) | ALKMETFLT3EGFR | |
| SCHEMBL28436291 | 0.88 | ALK (0.86) | ALKMETFLT3EGFR | |
| SCHEMBL28430221 | 0.87 | ALK (0.82) | ALKMETFLT3EGFR | |
| SCHEMBL28441579 | 0.87 | ALK (0.85) | ALKMETFLT3EGFR | |
| SCHEMBL28431751 | 0.86 | ALK (0.85) | ALKMETPTK2 | |
| SCHEMBL28430882 | 0.86 | ALK (0.84) | ALKMETFLT3PTK2EGFR | |
| SCHEMBL28434053 | 0.86 | ALK (1.00) | ALKMETFLT3PTK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111484484-B | 2, 4-diaryl aminopyrimidine derivative containing aromatic heterocycle and preparation and application thereof | 沈阳药科大学 | 2021-11-23 | — | — | CN | claimed |
| CN-111484484-A | 2, 4-diaryl aminopyrimidine derivative containing aromatic heterocycle and preparation and application thereof | 沈阳药科大学 | 2020-08-04 | — | — | CN | claimed |
| CN-111484484-B | 2, 4-diaryl aminopyrimidine derivative containing aromatic heterocycle and preparation and application thereof | 沈阳药科大学 | 2021-11-23 | — | — | CN | disclosed |
| CN-111484484-A | 2, 4-diaryl aminopyrimidine derivative containing aromatic heterocycle and preparation and application thereof | 沈阳药科大学 | 2020-08-04 | — | — | CN | disclosed |