Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 10/20 | 0.70 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.68 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.68 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.68 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.68 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.68 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.68 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.68 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.51 |
| ▸ | RPS6KA5 | O75582 | 4/20 | 0.51 |
| ▸ | AKT1 | P31749 | 4/20 | 0.51 |
| ▸ | GSK3B | P49841 | 4/20 | 0.51 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.51 |
| ▸ | PRKG2 | Q13237 | 4/20 | 0.51 |
| ▸ | PRKG1 | Q13976 | 4/20 | 0.51 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2842461 | 0.88 | HDAC4 (0.81) | HDAC4HDAC7HDAC5HDAC6HDAC1 | |
| SCHEMBL2864046 | 0.88 | HDAC4 (0.60) | HDAC4HDAC7HDAC5HDAC6HDAC1 | |
| SCHEMBL20490658 | 0.88 | HDAC4 (0.60) | HDAC4HDAC7HDAC5HDAC6HDAC1 | |
| SCHEMBL2840256 | 0.85 | HDAC4 (0.60) | HDAC4HDAC7HDAC5HDAC6HDAC1 | |
| SCHEMBL2842606 | 0.84 | HDAC4 (0.71) | HDAC4HDAC7HDAC5HDAC6HDAC1 | |
| SCHEMBL2839032 | 0.82 | HDAC4 (1.00) | HDAC4HDAC7HDAC5HDAC6HDAC1 | |
| SCHEMBL20490123 | 0.82 | HDAC4 (0.70) | HDAC4HDAC7HDAC5HDAC6HDAC1 | |
| SCHEMBL20490227 | 0.82 | HDAC4 (0.70) | HDAC4HDAC7HDAC5HDAC6HDAC1 | |
| SCHEMBL2840995 | 0.82 | HDAC4 (0.77) | HDAC4HDAC7HDAC5HDAC6HDAC1 | |
| SCHEMBL2840844 | 0.82 | HDAC4 (0.77) | HDAC4HDAC7HDAC5HDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139850-B1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC (CA) | 2018-09-12 | — | — | EP | claimed |
| CN-101679220-A | Histone deacetylase inhibitor | METHYLGENE INC | 2010-03-24 | — | — | CN | claimed |
| EP-2139850-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2010-01-06 | — | — | EP | claimed |
| US-20090181943-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2009-07-16 | — | — | US | claimed |
| WO-2008122115-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2008-10-16 | — | — | WO | claimed |
| EP-2139850-B1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC (CA) | 2018-09-12 | — | — | EP | disclosed |
| US-9096565-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2015-08-04 | — | — | US | disclosed |
| US-9096565-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2015-08-04 | — | — | US | disclosed |
| US-9096565-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2015-08-04 | — | — | US | disclosed |
| CN-101679220-A | Histone deacetylase inhibitor | METHYLGENE INC | 2010-03-24 | — | — | CN | disclosed |
| EP-2139850-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2010-01-06 | — | — | EP | disclosed |
| US-20090181943-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2009-07-16 | — | — | US | disclosed |
| US-20090181943-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2009-07-16 | — | — | US | disclosed |
| US-20090181943-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2009-07-16 | — | — | US | disclosed |
| WO-2008122115-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2008-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181943-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC11, HDAC3 | HDAC4 10/4885HDAC7 7/4885HDAC5 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.