Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | IGF1R | P08069 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 4/20 | 0.55 |
| ▸ | FLT3 | P36888 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 3/20 | 0.52 |
| ▸ | RGS12 | O14924 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24426177 | 0.84 | JAK2 (0.76) | MAPTMAPK1TP53IGF1RJAK2 | |
| SCHEMBL29669890 | 0.83 | JAK2 (0.75) | JAK2FLT3AURKASYK | |
| SCHEMBL28437339 | 0.83 | JAK2 (0.75) | JAK2FLT3AURKASYK | |
| SCHEMBL28434558 | 0.83 | PIK3CD (0.53) | MAPTMAPK1TP53ALDH1A1KMT2A | |
| SCHEMBL22860800 | 0.82 | JAK2 (0.59) | MAPTMAPK1TP53IGF1RJAK2 | |
| SCHEMBL12486039 | 0.79 | MAPT (0.67) | MAPTMAPK1TP53IGF1RKDM4E | |
| SCHEMBL28434556 | 0.78 | TAAR1 (0.53) | — | |
| SCHEMBL28441100 | 0.78 | JAK2 (0.61) | JAK2FLT3SYK | |
| SCHEMBL12485812 | 0.77 | MAPT (0.64) | MAPTMAPK1TP53IGF1RKDM4E | |
| SCHEMBL30839088 | 0.77 | JAK2 (0.64) | JAK2FLT3AURKASYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | claimed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | claimed |
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | disclosed |