Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 13/20 | 0.89 |
| ▸ | FLT3 | P36888 | 3/20 | 0.89 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | CCNK | O75909 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CCND3 | P30281 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.51 |
| ▸ | ROS1 | P08922 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | AXL | P30530 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28435828 | 0.94 | ALK (1.00) | ALKFLT3METROS1EGFR | |
| SCHEMBL28434966 | 0.94 | ALK (0.98) | ALKFLT3METGRIN1GRIN2B | |
| SCHEMBL28438911 | 0.93 | ALK (1.00) | ALKFLT3METGRIN1GRIN2B | |
| SCHEMBL28438915 | 0.92 | ALK (0.88) | ALKFLT3METGRIN1GRIN2B | |
| SCHEMBL28438025 | 0.92 | ALK (0.86) | ALKFLT3METCCNKCCNA2 | |
| SCHEMBL28431615 | 0.92 | ALK (0.86) | ALKFLT3METGRIN1GRIN2B | |
| SCHEMBL28430784 | 0.91 | ALK (0.85) | ALKFLT3METGRIN1GRIN2B | |
| SCHEMBL28430807 | 0.90 | ALK (0.84) | ALKFLT3METGRIN1GRIN2B | |
| SCHEMBL28435539 | 0.86 | ALK (1.00) | ALKFLT3METROS1EGFR | |
| SCHEMBL28435527 | 0.86 | ALK (0.86) | ALKFLT3METROS1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111484484-B | 2, 4-diaryl aminopyrimidine derivative containing aromatic heterocycle and preparation and application thereof | 沈阳药科大学 | 2021-11-23 | — | — | CN | claimed |
| CN-111484484-A | 2, 4-diaryl aminopyrimidine derivative containing aromatic heterocycle and preparation and application thereof | 沈阳药科大学 | 2020-08-04 | — | — | CN | claimed |
| CN-111484484-B | 2, 4-diaryl aminopyrimidine derivative containing aromatic heterocycle and preparation and application thereof | 沈阳药科大学 | 2021-11-23 | — | — | CN | disclosed |
| CN-111484484-A | 2, 4-diaryl aminopyrimidine derivative containing aromatic heterocycle and preparation and application thereof | 沈阳药科大学 | 2020-08-04 | — | — | CN | disclosed |