Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.63 |
| ▸ | FLT3 | P36888 | 6/20 | 0.63 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.46 |
| ▸ | GOT1 | P17174 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ROS1 | P08922 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28443652 | 0.91 | JAK2 (0.64) | JAK2FLT3PIK3R1PIK3CAMTOR | |
| SCHEMBL28443297 | 0.88 | JAK2 (0.60) | JAK2FLT3PIK3R1PIK3CAMTOR | |
| SCHEMBL28443648 | 0.88 | JAK2 (0.60) | JAK2FLT3PIK3R1PIK3CAMTOR | |
| SCHEMBL24426171 | 0.88 | JAK2 (0.81) | JAK2FLT3PIK3R1PIK3CAMTOR | |
| SCHEMBL28442567 | 0.85 | PIK3R1 (0.67) | JAK2FLT3PIK3R1PIK3CAMTOR | |
| SCHEMBL28442731 | 0.84 | JAK2 (0.77) | JAK2FLT3PIK3R1PIK3CAMTOR | |
| SCHEMBL28442021 | 0.84 | POLB (0.45) | MTORALDH1A1KDM4ESMN1; SMN2POLB | |
| SCHEMBL28434562 | 0.81 | JAK2 (0.52) | JAK2FLT3ALDH1A1FGFR4MAPT | |
| SCHEMBL28445184 | 0.80 | JAK2 (0.58) | JAK2FLT3PIK3R1PIK3CAMTOR | |
| SCHEMBL28434570 | 0.80 | JAK2 (0.51) | JAK2FLT3PIK3R1PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | disclosed |