Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER2 | P43116 | 18/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 18/20 | 0.49 |
| ▸ | PTGER3 | P43115 | 5/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28436244 | 1.00 | PTGER2 (0.49) | PTGER2PTGER4PTGER3HRH3 | |
| SCHEMBL15551396 | 0.90 | PTGER4 (0.40) | PTGER2PTGER4 | |
| SCHEMBL15551397 | 0.90 | PTGER4 (0.40) | PTGER2PTGER4 | |
| SCHEMBL22159604 | 0.90 | PTGER4 (0.40) | PTGER2PTGER4 | |
| SCHEMBL28425687 | 0.79 | PTGER2 (0.57) | PTGER2PTGER4 | |
| SCHEMBL28425686 | 0.79 | PTGER2 (0.57) | PTGER2PTGER4 | |
| SCHEMBL18942726 | 0.76 | PTGER4 (0.57) | PTGER2PTGER4PTGER3HRH3 | |
| SCHEMBL28425760 | 0.75 | PTGER4 (0.64) | PTGER2PTGER4PTGER3 | |
| SCHEMBL15549241 | 0.75 | PTGER4 (0.64) | PTGER2PTGER4PTGER3 | |
| SCHEMBL16403846 | 0.74 | PTGER4 (0.52) | PTGER2PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107802623-B | Difluorolactam compositions for EP 4-mediated bone-related diseases and disorders | 开曼化学股份有限公司 | 2020-10-30 | — | — | CN | disclosed |
| CN-106748951-B | Difluorolactam compounds as EP4 receptor selective agonists for use in the treatment of EP4 mediated diseases and conditions | 开曼化学股份有限公司 | 2020-07-24 | — | — | CN | disclosed |