Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10562193 | 1.00 | SLC18A3 (0.57) | SLC18A3KMT2AALDH1A1KDM4ECA1 | |
| SCHEMBL31122399 | 1.00 | SLC18A3 (0.57) | SLC18A3KMT2AALDH1A1KDM4ECA1 | |
| SCHEMBL30456355 | 1.00 | SLC18A3 (0.57) | SLC18A3KMT2AALDH1A1KDM4ECA1 | |
| SCHEMBL11245821 | 1.00 | SLC18A3 (0.57) | SLC18A3KMT2AALDH1A1KDM4ECA1 | |
| SCHEMBL30456604 | 1.00 | SLC18A3 (0.57) | SLC18A3KMT2AALDH1A1KDM4ECA1 | |
| SCHEMBL23595723 | 1.00 | SLC18A3 (0.57) | SLC18A3KMT2AALDH1A1KDM4ECA1 | |
| SCHEMBL13917788 | 1.00 | SLC18A3 (0.57) | SLC18A3KMT2AALDH1A1KDM4ECA1 | |
| SCHEMBL491782 | 1.00 | SLC18A3 (0.57) | SLC18A3KMT2AALDH1A1KDM4ECA1 | |
| SCHEMBL7343040 | 0.98 | SLC18A3 (0.59) | SLC18A3KMT2AALDH1A1KDM4ECA1 | |
| SCHEMBL304915 | 0.96 | SLC18A3 (0.56) | SLC18A3KMT2AALDH1A1KDM4ECA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113620974-B | Crystal form of macrocyclic tyrosine kinase inhibitor and preparation method thereof | 山东轩竹医药科技有限公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-113135938-B | Substituted macrocyclic tyrosine kinase inhibitors and uses thereof | 山东轩竹医药科技有限公司 | 2022-06-14 | — | — | CN | disclosed |
| CN-110577532-B | Tropomyosin receptor kinase inhibitor and preparation method and application thereof | 江苏威凯尔医药科技有限公司 | 2022-06-03 | — | — | CN | disclosed |
| CN-111592541-A | Macrocyclic kinase inhibitors and uses thereof | 山东轩竹医药科技有限公司 | 2020-08-28 | — | — | CN | disclosed |