Lithocholic Acid

Lithocholic Acid

SCHEMBL28449

C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPBAR1 Q8TDU6 7/20 1.00
EPHA2 P29317 4/20 1.00
CASP7 P55210 3/20 1.00
VDR P11473 3/20 1.00
HIF1A Q16665 3/20 1.00
TP53 P04637 2/20 1.00
MAPK1 P28482 2/20 1.00
HSD17B10 Q99714 2/20 1.00
BLM P54132 2/20 1.00
TDP1 Q9NUW8 2/20 1.00
USP2 O75604 2/20 1.00
CYP3A4 P08684 2/20 1.00
NR1H4 Q96RI1 2/20 1.00
LMNA P02545 2/20 1.00
MDM4 O15151 1/20 1.00
MAPT P10636 1/20 1.00
HSPD1 P10809 1/20 1.00
TSHR P16473 1/20 1.00
PTPN2 P17706 1/20 1.00
PTPN1 P18031 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lithocholic Acid SCHEMBL22756077 1.00 GPBAR1 (1.00) GPBAR1EPHA2CASP7VDRHIF1A
Lithocholic Acid SCHEMBL22894393 1.00 GPBAR1 (1.00) GPBAR1EPHA2CASP7VDRHIF1A
Lithocholic Acid SCHEMBL22871939 1.00 GPBAR1 (1.00) GPBAR1EPHA2CASP7VDRHIF1A
Lithocholic Acid SCHEMBL22079173 1.00 GPBAR1 (1.00) GPBAR1EPHA2CASP7VDRHIF1A
Lithocholic Acid SCHEMBL24001494 1.00 GPBAR1 (1.00) GPBAR1EPHA2CASP7VDRHIF1A
Lithocholic Acid SCHEMBL22894425 1.00 GPBAR1 (1.00) GPBAR1EPHA2CASP7VDRHIF1A
Lithocholic Acid SCHEMBL23923735 1.00 GPBAR1 (1.00) GPBAR1EPHA2CASP7VDRHIF1A
Lithocholic Acid SCHEMBL24001453 1.00 GPBAR1 (1.00) GPBAR1EPHA2CASP7VDRHIF1A
Lithocholic Acid SCHEMBL24567422 1.00 GPBAR1 (1.00) GPBAR1EPHA2CASP7VDRHIF1A
Lithocholic Acid SCHEMBL22415871 1.00 GPBAR1 (1.00) GPBAR1EPHA2CASP7VDRHIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 17802 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4747627-A1 METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS Matterworks Inc (US) 2026-05-27 EP claimed
WO-2026107335-A1 COMPOSITIONS AND METHODS FOR TREATING HEPATIC DISEASES BY INHIBITING EFHD1 UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2026-05-21 WO claimed
US-20260139254-A1 INTERFERING RNA FOR INHIBITING TOP1 GENE EXPRESSION AND USE THEREOF JENKEM TECH CO LTD BEIJING (CN) 2026-05-21 US claimed
EP-4743061-A1 FORMULATIONS OF NUCLEIC ACID COMPOUNDS AND USES THEREOF Comanche Biopharma Corp. (US) 2026-05-20 EP claimed
CN-122070276-A Prodrugs of xanomeline, prodrugs of trospium chloride and methods of using the same 人类生物科学股份有限公司 2026-05-19 CN claimed
CN-224252822-U Reaction kettle for producing lithocholic acid intermediate 平顶山隆维生物科技有限公司 2026-05-19 CN claimed
CN-122055161-A Microbiota Restoration Therapy (MRT) compositions and methods of administration 辉凌微生物组有限公司 2026-05-15 CN claimed
EP-3869192-B1 METHOD FOR QUANTITATIVE DETECTION OF VARIOUS METABOLITES IN BIOLOGICAL SAMPLE HUMAN METABOLOMICS INST INC (CN) 2026-05-13 EP claimed
CN-122010656-A Application of oxyalkylisourea in introducing methyl and isotopically-labeled methyl 陕西师范大学 2026-05-12 CN claimed
CN-122017068-A Bile acid high-flux detection method based on ultra-high performance liquid chromatography tandem mass spectrometry and application thereof 青岛百谱生物科技有限公司 2026-05-12 CN claimed
WO-1983003604-A1 A PROCESS FOR PREPARING SUBSTITUTED POLYCYCLO-ALKYLIDENE POLYCYCLO-ALKANES AND THE CORRESPONDING EPIDIOXY COMPOUNDS; AS WELL AS SAID SUBSTITUTED POLYCYCLO-ALKYLIDENE POLYCYCLO-ALKANES AND THE CORRESPONDING EPIDIOXY COMPOUNDS HUMMELEN, JAN, CORNELIS 1983-10-27 WO claimed
EP-0088637-A2 A method for producing ursodeoxycholic acid KABUSHIKI KAISHA YAKULT HONSHA (JP) 1983-09-14 EP claimed
US-4400461-A O-NITROARYLMETHYL ESTERS OF CARBOXYLIC ACIDS, POLYMER BELL TELEPHONE LABORATORIES, INCORPORATED (US) 1983-08-23 US claimed
US-4354972-A Synthesis of steroids KAISER EMIL T 1982-10-19 US claimed
EP-0058000-A2 Cosmetic composition UNILEVER PLC (GB) 1982-08-18 EP claimed
US-4331607-A Process for the purification of chenodeoxycholic acid BLASINACHIM S.P.A. (IT) 1982-05-25 US claimed
US-4277408-A Novel purification process ROUSSEL UCLAF (FR) 1981-07-07 US claimed
US-4207308-A BY EXTRACTION AND CHROMATOGRAPHY THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF VETERANS AFFAIRS (US) 1980-06-10 US claimed
US-4171352-A Quantitative evaluation of enteric microbial overgrowth POLYSCIENCES, INC. (US) 1979-10-16 US claimed
US-3944578-A Organic superconductors with high transition temperatures and high critical magnetic fields THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1976-03-16 US claimed