Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.63 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.63 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.63 |
| ▸ | PGR | P06401 | 1/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.63 |
| ▸ | HTR2B | P41595 | 1/20 | 0.63 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.63 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.38 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.38 |
| ▸ | MME | P08473 | 2/20 | 0.37 |
| ▸ | BHMT | Q93088 | 1/20 | 0.35 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4412290 | 0.91 | CACNA2D1 (0.74) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| SCHEMBL11762538 | 0.88 | CACNA2D1 (0.71) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| SCHEMBL968570 | 0.85 | CACNA2D1 (0.54) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| SCHEMBL5536469 | 0.85 | CACNA2D1 (0.54) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| SCHEMBL1410027 | 0.85 | CACNA2D1 (0.74) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| SCHEMBL3783223 | 0.83 | CACNA2D1 (0.52) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| Ammonia Solution, Strong SCHEMBL28027924 | 0.83 | CACNA2D1 (0.52) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| SCHEMBL2171052 | 0.81 | CACNA2D1 (0.50) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| SCHEMBL14359978 | 0.80 | CACNA2D1 (0.46) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| SCHEMBL12878966 | 0.79 | CACNA2D1 (0.65) | CACNA2D1CACNB3CACNA1CPGRADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2174958-A1 | Antibodies derived from anti ed-b l19 and targeting tumor vasculature | Philogen S.p.A. (IT) | 2010-04-14 | — | — | EP | disclosed |
| CN-100482285-C | Targeting of tumor vasculature using radiolabelled antibody l19 against fibronectin ED-B | PHILOGEN S P A SCHERING AG (IT) | 2009-04-29 | — | — | CN | disclosed |
| CN-1849144-A | Targeting of tumor vasculature using radiolabelled antibody l19 against fibronectin ED-B | PHILOGEN SPA (IT) | 2006-10-18 | — | — | CN | disclosed |
| EP-1663320-A1 | TARGETING OF TUMOR VASCULATURE USING RADIOLABELLED ANTIBODY L19 AGAINST FIBRONECTIN ED-B | Philogen S.p.A. (IT) | 2006-06-07 | — | — | EP | disclosed |
| WO-2003076469-A9 | ANTIBODIES DERIVED ROM ANTI ED-B L19 AND TARGETING TUMOR VASCULATURE | PHILOGEN SPA (IT) | 2005-09-29 | — | — | WO | disclosed |
| WO-2005023318-A1 | TARGETING OF TUMOR VASCULATURE USING RADIOLABELLED ANTIBODY L19 AGAINST FIBRONECTIN ED-B | PHILOGEN S.P.A (IT) | 2005-03-17 | — | — | WO | disclosed |
| EP-1483297-A2 | ANTIBODIES DERIVED FROM ANTI ED-B L19 AND TARGETING TUMOR VASCULATURE | Philogen S.p.A. (IT) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003076469-A2 | ANTIBODIES DERIVED ROM ANTI ED-B L19 AND TARGETING TUMOR VASCULATURE | PHILOGEN S.P.A. (IT) | 2003-09-18 | — | — | WO | disclosed |