SCHEMBL2845115

SCHEMBL2845115

CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(CC(C)O)c(C)cc12

nearest known ligand 0.45

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 9/20 0.45
CYP2C8 P10632 6/20 0.45
KCNH2 Q12809 4/20 0.44
NR1I2 O75469 1/20 0.42
CYP2C9 P11712 4/20 0.42
CYP2C19 P33261 4/20 0.42
ANO1 Q5XXA6 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2845478 0.90 CYP3A4 (0.43) CYP3A4CYP2C8KCNH2CYP2C9CYP2C19
SCHEMBL17464372 0.88 CYP3A4 (0.49) CYP3A4CYP2C8KCNH2NR1I2CYP2C9
SCHEMBL2838542 0.87 ANO1 (0.41) CYP3A4CYP2C8KCNH2NR1I2CYP2C9
SCHEMBL2840278 0.86 CYP3A4 (0.40) CYP3A4CYP2C8KCNH2NR1I2CYP2C9
SCHEMBL17464344 0.85 CYP3A4 (0.47) CYP3A4CYP2C8KCNH2NR1I2CYP2C9
SCHEMBL19797951 0.84 CYP3A4 (0.52) CYP3A4CYP2C8KCNH2NR1I2CYP2C9
SCHEMBL17464374 0.83 CYP3A4 (0.47) CYP3A4CYP2C8KCNH2NR1I2CYP2C9
SCHEMBL17464360 0.83 CYP3A4 (0.45) CYP3A4CYP2C8KCNH2NR1I2CYP2C9
SCHEMBL12940354 0.82 CYP3A4 (0.47) CYP3A4CYP2C8KCNH2NR1I2CYP2C9
SCHEMBL17464353 0.81 CYP3A4 (0.45) CYP3A4CYP2C8KCNH2NR1I2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4537315-B2 2010-09-01 JP claimed
EP-1581207-A4 BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES VIROPHARMA INC (US) 2007-07-25 EP claimed
JP-2006510736-A 2006-03-30 JP claimed
EP-1581207-A2 BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES Viropharma Incorporated (US) 2005-10-05 EP claimed
WO-2004041201-A2 BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES VIROPHARMA INCORPORATED (US) 2004-05-21 WO claimed