Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 13/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL66972 | 0.90 | CACNA1B (0.56) | CACNA1BLMNASMN1; SMN2GAA | |
| SCHEMBL16497986 | 0.85 | CACNA1B (0.61) | CACNA1BLMNASMN1; SMN2 | |
| SCHEMBL16497704 | 0.85 | CACNA1B (0.61) | CACNA1BLMNASMN1; SMN2 | |
| SCHEMBL16497855 | 0.85 | CACNA1B (0.61) | CACNA1BLMNASMN1; SMN2 | |
| SCHEMBL2422335 | 0.84 | CACNA1B (0.60) | CACNA1BLMNASMN1; SMN2 | |
| SCHEMBL2844339 | 0.84 | CACNA1B (0.60) | CACNA1BLMNASMN1; SMN2 | |
| SCHEMBL66973 | 0.83 | CACNA1B (0.55) | CACNA1BLMNASMN1; SMN2GAA | |
| SCHEMBL66959 | 0.83 | CACNA1B (0.62) | CACNA1BLMNASMN1; SMN2GAA | |
| SCHEMBL2422009 | 0.81 | CACNA1B (0.72) | CACNA1BLMNA | |
| SCHEMBL66782 | 0.78 | CACNA1B (0.58) | CACNA1BLMNASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130558-A1 | NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA[C]PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS | ABBOTT LABORATORIES (US) | 2010-05-27 | — | — | US | claimed |
| WO-2011149995-A1 | NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA [C]PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS | ABBOTT LABORATORIES (US) | 2011-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130558-A1 | NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA[C]PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS | CACNA1C, ORAI1, CACNA1S | CACNA1B 5/4885LMNA 598/4885SMN1; SMN2 1139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.