Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 19/20 | 1.00 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28455001 | 1.00 | IDH2 (1.00) | IDH2AURKA | |
| SCHEMBL28451468 | 1.00 | IDH2 (1.00) | IDH2AURKA | |
| SCHEMBL28450742 | 0.90 | IDH2 (1.00) | IDH2 | |
| SCHEMBL28454996 | 0.90 | IDH2 (1.00) | IDH2 | |
| SCHEMBL30568810 | 0.90 | IDH2 (1.00) | IDH2 | |
| SCHEMBL28450741 | 0.90 | IDH2 (1.00) | IDH2 | |
| SCHEMBL30568851 | 0.90 | IDH2 (1.00) | IDH2 | |
| SCHEMBL28476068 | 0.88 | IDH2 (0.79) | IDH2 | |
| SCHEMBL28468263 | 0.88 | IDH2 (0.79) | IDH2 | |
| SCHEMBL28475669 | 0.88 | IDH2 (0.79) | IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111662242-B | Heterocyclic IDH mutant inhibitor, preparation method and application thereof | 中国药科大学 | 2023-10-24 | — | — | CN | disclosed |
| CN-111662242-A | Heterocyclic IDH mutant inhibitor, preparation method and application thereof | 中国药科大学 | 2020-09-15 | — | — | CN | disclosed |