SCHEMBL28451981

SCHEMBL28451981

COc1cccc(-c2cnccc2NS(=O)(=O)C(F)(F)F)c1

nearest known ligand 0.74

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
SLC22A12 Q96S37 6/20 0.74
PTGS1 P23219 13/20 0.67
PTGS2 P35354 11/20 0.67
RPS6KA3 P51812 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28455873 0.85 SLC22A12 (1.00) SLC22A12PTGS1PTGS2RPS6KA3
SCHEMBL28454370 0.85 SLC22A12 (1.00) SLC22A12PTGS1PTGS2
SCHEMBL28452209 0.83 SLC22A12 (0.78) SLC22A12PTGS1PTGS2RPS6KA3
SCHEMBL28452095 0.81 SLC22A12 (0.74) SLC22A12PTGS1
SCHEMBL28898091 0.80 SLC22A12 (0.66) SLC22A12PTGS1PTGS2
SCHEMBL28444446 0.80 SLC22A12 (0.71) SLC22A12PTGS1PTGS2RPS6KA3
SCHEMBL28898093 0.78 SLC22A12 (0.75) SLC22A12PTGS1PTGS2
SCHEMBL28452434 0.77 SLC22A12 (1.00) SLC22A12PTGS1PTGS2
SCHEMBL28446113 0.75 SLC22A12 (0.74) SLC22A12PTGS1PTGS2
SCHEMBL14689917 0.71 PTGS1 (0.63) PTGS1PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106831556-B Sulfonamide compound, preparation method thereof and application of sulfonamide compound as urate transporter inhibitor medicine 成都海创药业有限公司 2020-09-01 CN disclosed