SCHEMBL28452007

SCHEMBL28452007

COc1ccc(C(CC(F)(F)C(F)(F)C(F)(F)C(F)(F)F)OOC(C)(C)C)cc1

nearest known ligand 0.35

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
AOC3 Q16853 4/20 0.35
ALDH1A1 P00352 1/20 0.34
TSHR P16473 1/20 0.34
MAPK1 P28482 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
NPSR1 Q6W5P4 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C19 P33261 1/20 0.32
SLC6A9 P48067 1/20 0.31
PDK1 Q15118 1/20 0.31
PDK2 Q15119 1/20 0.31
PDK3 Q15120 1/20 0.31
PDK4 Q16654 1/20 0.31
HSD11B1 P28845 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28321941 0.86 AOC3 (0.34) AOC3
SCHEMBL28452010 0.86
SCHEMBL28320895 0.86
SCHEMBL28320890 0.85 SLC6A4 (0.33) ALDH1A1TSHRMAPK1CYP1A2CYP2D6
SCHEMBL28441002 0.85 AOC3 (0.33) AOC3
SCHEMBL28320891 0.85
SCHEMBL28321935 0.85
SCHEMBL28441514 0.85 SLC6A4 (0.32) ALDH1A1TSHRMAPK1CYP1A2CYP2D6
SCHEMBL28322014 0.84 TSHR (0.32) TSHRMAPK1TDP1L3MBTL1
SCHEMBL28439723 0.83 SLC6A4 (0.32) ALDH1A1TSHRMAPK1CYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110357842-B Fluoroalkyl substituted furan compound and preparation method thereof 南京工业大学 2022-12-16 CN claimed
CN-111574564-A Fluoroalkyl-substituted furyl diphosphine oxygen compound and preparation method thereof 南京工业大学 2020-08-25 CN claimed
CN-111560038-A Fluoroalkyl-substituted furyl monophosphine oxide compound and preparation method thereof 南京工业大学 2020-08-21 CN claimed
CN-110357842-A Fluoroalkyl substituted furan compound and preparation method thereof 南京工业大学 2019-10-22 CN claimed
CN-110357842-B Fluoroalkyl substituted furan compound and preparation method thereof 南京工业大学 2022-12-16 CN disclosed
CN-111574564-A Fluoroalkyl-substituted furyl diphosphine oxygen compound and preparation method thereof 南京工业大学 2020-08-25 CN disclosed
CN-111560038-A Fluoroalkyl-substituted furyl monophosphine oxide compound and preparation method thereof 南京工业大学 2020-08-21 CN disclosed
CN-110357842-A Fluoroalkyl substituted furan compound and preparation method thereof 南京工业大学 2019-10-22 CN disclosed