Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 6/20 | 0.67 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.43 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | TTK | P33981 | 4/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4920465 | 0.75 | TTK (0.51) | CDK1CCNB1CDK2EGFRPDPK1 | |
| SCHEMBL20654492 | 0.72 | FLT3 (0.45) | PAK4CCNB2CDK1CCNB1CCNA2 | |
| SCHEMBL23690869 | 0.69 | JAK3 (0.62) | EGFRJAK2JAK3 | |
| SCHEMBL31085501 | 0.69 | JAK3 (0.62) | EGFRJAK2JAK3 | |
| SCHEMBL28446369 | 0.68 | PAK4 (1.00) | PAK4TTBK1TTBK2 | |
| SCHEMBL28446370 | 0.68 | PAK4 (1.00) | PAK4TTBK1TTBK2 | |
| SCHEMBL28450012 | 0.68 | PAK4 (1.00) | PAK4TTBK1TTBK2 | |
| SCHEMBL20183342 | 0.67 | JAK3 (0.76) | JAK2JAK3 | |
| SCHEMBL28455827 | 0.66 | PAK4 (0.78) | PAK4 | |
| SCHEMBL28456610 | 0.65 | PAK4 (0.65) | PAK4TTBK1TTBK2TTKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111620878-A | Pyrrolopyrimidine derivatives as protein kinase inhibitors and application thereof | 中国药科大学 | 2020-09-04 | — | — | CN | disclosed |