Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2845466 | 0.81 | PDE4B (0.68) | PDE4BPDE3ANR1H2 | |
| SCHEMBL2850758 | 0.81 | PDE4B (0.58) | PDE4BPDE3ASLC6A2PDE4DNR1H2 | |
| SCHEMBL2844371 | 0.80 | PDE4B (0.69) | PDE4BPDE3APDE4DNR1H2 | |
| SCHEMBL3119075 | 0.79 | PDE4B (0.62) | PDE4BPDE3ASLC6A2PDE4D | |
| SCHEMBL2850960 | 0.79 | PDE4B (0.63) | PDE4BPDE3APDE4D | |
| SCHEMBL3122953 | 0.78 | PDE4B (0.47) | PDE4BPDE3APDE4D | |
| SCHEMBL2852198 | 0.75 | PDE4B (0.68) | PDE4BPDE3ASLC6A2PDE4DALDH1A1 | |
| SCHEMBL2842070 | 0.75 | PDE4B (0.42) | PDE4BPDE3ASLC6A2PDE4DALDH1A1 | |
| SCHEMBL2847616 | 0.74 | PDE4B (1.00) | PDE4BPDE3AALDH1A1HPGDHSD17B10 | |
| SCHEMBL2845290 | 0.74 | PDE4B (0.43) | PDE4BPDE3ASLC6A2PDE4DNR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130738-A1 | PYRAZOLONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2010-05-27 | — | — | US | disclosed |
| US-20100130738-A1 | PYRAZOLONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2010-05-27 | — | — | US | disclosed |
| US-20100130738-A1 | PYRAZOLONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2010-05-27 | — | — | US | disclosed |
| EP-2168960-A1 | PYRAZOLONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT | Kyorin Pharmaceutical Co., Ltd. (JP) | 2010-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130738-A1 | PYRAZOLONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT | PDE3A, PDE3B, PDE2A | PDE4B 6/4885PDE3A 1/4885SLC6A2 3866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.