Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.46 |
| ▸ | SETD7 | Q8WTS6 | 2/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | SPR | P35270 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2843452 | 1.00 | HRH3 (0.49) | HRH3GPR119SETD7ACACBSPR | |
| SCHEMBL2843455 | 1.00 | HRH3 (0.49) | HRH3GPR119SETD7ACACBSPR | |
| SCHEMBL22770577 | 0.78 | HPGD (0.51) | GPR119SETD7SPRHSD11B1 | |
| SCHEMBL22770575 | 0.78 | HPGD (0.51) | GPR119SETD7SPRHSD11B1 | |
| SCHEMBL13320902 | 0.77 | HRH3 (0.63) | HRH3CYP2D6CYP2C19 | |
| SCHEMBL2850253 | 0.76 | HRH3 (0.69) | HRH3CYP2D6CYP2C19 | |
| SCHEMBL2842453 | 0.76 | HRH3 (0.69) | HRH3CYP2D6CYP2C19 | |
| SCHEMBL2842450 | 0.76 | HRH3 (0.69) | HRH3CYP2D6CYP2C19 | |
| SCHEMBL15776468 | 0.75 | GAA (0.53) | GPR119SETD7HSD11B1 | |
| SCHEMBL15055295 | 0.75 | HPGD (0.52) | GPR119SETD7HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010062245-A1 | SPIROCYCLOBUTYL PIPERIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2010-06-03 | — | — | WO | disclosed |
| US-20100130477-A1 | Spirocyclobutyl Piperidine Derivatives | ASTRAZENECA AB (SE) | 2010-05-27 | — | — | US | disclosed |
| US-20100130477-A1 | Spirocyclobutyl Piperidine Derivatives | ASTRAZENECA AB (SE) | 2010-05-27 | — | — | US | disclosed |
| US-20100130477-A1 | Spirocyclobutyl Piperidine Derivatives | ASTRAZENECA AB (SE) | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130477-A1 | Spirocyclobutyl Piperidine Derivatives | HRH3, HRH4, HRH2 | HRH3 1/4885GPR119 42/4885SETD7 684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.