Guanosine

Guanosine

SCHEMBL2845388

Nc1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1.OCC(O)CO

nearest known ligand 0.68

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Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 1/20 0.68
▸ HINT1 P49773 4/20 0.61
▸ NT5E P21589 2/20 0.61
▸ PNP P00491 2/20 0.59
▸ PAX8 Q06710 1/20 0.59
▸ GSK3A P49840 2/20 0.58
▸ RPS6KA3 P51812 2/20 0.58
▸ MAPK14 Q16539 2/20 0.58
▸ TGM2 P21980 1/20 0.57
▸ LMNA P02545 1/20 0.56
▸ HIF1A Q16665 1/20 0.56
▸ ADORA2A P29274 3/20 0.56
▸ ADORA3 P0DMS8 1/20 0.56
▸ ADORA2B P29275 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guanosine SCHEMBL12959061 0.94 HPGD (0.76) HPGDHINT1NT5EPNPPAX8
Guanosine SCHEMBL5550180 0.94 HPGD (0.76) HPGDHINT1NT5EPNPPAX8
Guanosine SCHEMBL973437 0.94 HPGD (0.76) HPGDHINT1NT5EPNPPAX8
Guanosine SCHEMBL24049608 0.94 HPGD (0.76) HPGDHINT1NT5EPNPPAX8
Guanosine SCHEMBL278157 0.94 HPGD (0.76) HPGDHINT1NT5EPNPPAX8
Guanosine SCHEMBL24049467 0.94 HPGD (0.76) HPGDHINT1NT5EPNPPAX8
Guanosine SCHEMBL24049417 0.94 HPGD (0.76) HPGDHINT1NT5EPNPPAX8
Guanosine SCHEMBL24049416 0.94 HPGD (0.76) HPGDHINT1NT5EPNPPAX8
Guanosine SCHEMBL20750695 0.94 HPGD (0.76) HPGDHINT1NT5EPNPPAX8
Guanosine SCHEMBL7062800 0.94 HPGD (0.76) HPGDHINT1NT5EPNPPAX8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106635799-A Screening method of guanosine production bacterial strains 广东肇庆星湖生物科技股份有限公司 2017-05-10 — — CN disclosed
CN-102757898-A Method for screening guanosine high-yielding strains through membrane culture WUHAN INST TECHNOLOGY 2012-10-31 — — CN disclosed
US-7741297-B2 Immunostimulatory, covalently lipidated oligonucleotides ONCOTHYREON INC. (US) 2010-06-22 — — US disclosed
US-20060189550-A1 Immunostimulatory, Covalently lipidated oligonucleotides BIOMIRA INC. (CA) 2006-08-24 — — US disclosed
EP-1474432-A1 IMMUNOSTIMULATORY, COVALENTLY LIPIDATED OLIGONUCLEOTIDES Biomira Inc. (CA) 2004-11-10 — — EP disclosed
WO-2003066649-A1 IMMUNOSTIMULATORY, COVALENTLY LIPIDATED OLIGONUCLEOTIDES BIOMIRA INC. (CA) 2003-08-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060189550-A1 Immunostimulatory, Covalently lipidated oligonucleotides TLR9, TLR3, STING1 HPGD 2779/4885HINT1 2450/4885NT5E 359/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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