Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 20/20 | 0.52 |
| ▸ | MAP2K2 | P36507 | 16/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | ACTR3 | P61158 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1488164 | 0.90 | MAP2K1 (0.66) | MAP2K1MAP2K2CHRM2CHRM1BRAF | |
| SCHEMBL29413411 | 0.90 | MAP2K1 (0.66) | MAP2K1MAP2K2CHRM2CHRM1BRAF | |
| SCHEMBL30220868 | 0.90 | MAP2K1 (0.66) | MAP2K1MAP2K2CHRM2CHRM1BRAF | |
| SCHEMBL1488293 | 0.90 | MAP2K1 (0.66) | MAP2K1MAP2K2CHRM2CHRM1BRAF | |
| Acetic Acid SCHEMBL1489056 | 0.87 | MAP2K1 (0.62) | MAP2K1MAP2K2CHRM2CHRM1BRAF | |
| SCHEMBL1489058 | 0.85 | MAP2K1 (0.52) | MAP2K1MAP2K2CHRM2CHRM1BRAF | |
| SCHEMBL1488138 | 0.82 | MAP2K1 (0.72) | MAP2K1MAP2K2CHRM2CHRM1BRAF | |
| SCHEMBL28454366 | 0.78 | MAP2K1 (0.40) | MAP2K1MAP2K2CHRM2CHRM1BRAF | |
| SCHEMBL4583757 | 0.77 | MAP2K1 (0.59) | MAP2K1MAP2K2CHRM2CHRM1BRAF | |
| SCHEMBL28445635 | 0.77 | MAP2K1 (0.74) | MAP2K1MAP2K2CHRM2CHRM1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111643496-A | Methods of using MEK inhibitors | 埃克塞利希斯股份有限公司 | 2020-09-11 | — | — | CN | disclosed |