Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 20/20 | 0.76 |
| ▸ | ABL1 | P00519 | 19/20 | 0.76 |
| ▸ | HCK | P08631 | 17/20 | 0.76 |
| ▸ | PIK3CD | O00329 | 16/20 | 0.76 |
| ▸ | PIK3CA | P42336 | 16/20 | 0.76 |
| ▸ | PIK3CB | P42338 | 16/20 | 0.76 |
| ▸ | PIK3CG | P48736 | 16/20 | 0.76 |
| ▸ | PRKDC | P78527 | 16/20 | 0.76 |
| ▸ | EGFR | P00533 | 16/20 | 0.76 |
| ▸ | KDR | P35968 | 15/20 | 0.76 |
| ▸ | MTOR | P42345 | 15/20 | 0.76 |
| ▸ | EPHB4 | P54760 | 15/20 | 0.76 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.73 |
| ▸ | LCK | P06239 | 2/20 | 0.64 |
| ▸ | EPHA3 | P29320 | 2/20 | 0.64 |
| ▸ | CSK | P41240 | 2/20 | 0.64 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.64 |
| ▸ | PLK4 | O00444 | 1/20 | 0.64 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.64 |
| ▸ | CASK | O14936 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24907281 | 0.91 | KDR (0.73) | SRCABL1HCKPIK3CDPIK3CA | |
| SCHEMBL2315798 | 0.84 | SRC (1.00) | SRCABL1HCKPIK3CDPIK3CA | |
| SCHEMBL29391405 | 0.81 | SRC (1.00) | SRCABL1HCKPIK3CDPIK3CA | |
| SCHEMBL14574867 | 0.81 | SRC (1.00) | SRCABL1HCKPIK3CDPIK3CA | |
| SCHEMBL18196381 | 0.81 | SRC (0.80) | SRCABL1HCKPIK3CDPIK3CA | |
| SCHEMBL2320180 | 0.80 | SRC (1.00) | SRCABL1HCKPIK3CDPIK3CA | |
| SCHEMBL2468132 | 0.80 | SRC (1.00) | SRCABL1HCKPIK3CDPIK3CA | |
| SCHEMBL12108174 | 0.79 | SRC (0.79) | SRCABL1HCKPIK3CDPIK3CA | |
| SCHEMBL14574574 | 0.79 | SRC (0.80) | SRCABL1HCKPIK3CDPIK3CA | |
| SCHEMBL3613345 | 0.79 | SRC (1.00) | SRCABL1HCKPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107075482-B | Treatment of cancer using anti-CD 19 chimeric antigen receptors | 诺华股份有限公司 | 2021-03-16 | — | — | CN | disclosed |
| CN-112481283-A | Treatment of cancer using CD33 chimeric antigen receptor | 诺华股份有限公司 | 2021-03-12 | — | — | CN | disclosed |
| CN-112410363-A | anti-CD 123 Chimeric Antigen Receptor (CAR) for cancer therapy | 诺华股份有限公司 | 2021-02-26 | — | — | CN | disclosed |
| CN-107109419-B | Treatment of cancer using CD33 chimeric antigen receptor | 诺华股份有限公司 | 2020-12-22 | — | — | CN | disclosed |
| CN-107108744-B | anti-CD 123 Chimeric Antigen Receptor (CAR) for cancer therapy | 诺华股份有限公司 | 2020-09-25 | — | — | CN | disclosed |
| CN-111514283-A | Treatment of cancer using anti-CD 19 chimeric antigen receptors | 诺华股份有限公司 | 2020-08-11 | — | — | CN | disclosed |