Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aminoglutethimide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 known ✓ | P11511 | 19/20 | 0.97 |
| ▸ | CYP11A1 known ✓ | P05108 | 1/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.97 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.97 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.97 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.97 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.97 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.97 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aminoglutethimide SCHEMBL4306 | 0.98 | CYP19A1 (1.00) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| Aminoglutethimide SCHEMBL116988 | 0.98 | CYP19A1 (1.00) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| Aminoglutethimide SCHEMBL1230613 | 0.98 | CYP19A1 (1.00) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| Aminoglutethimide SCHEMBL7728932 | 0.98 | CYP19A1 (1.00) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| Aminoglutethimide SCHEMBL28119771 | 0.95 | CYP19A1 (0.94) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| Aminoglutethimide SCHEMBL28329350 | 0.93 | CYP19A1 (0.89) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| Aminoglutethimide SCHEMBL11699322 | 0.92 | CYP19A1 (0.86) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| Aminoglutethimide SCHEMBL28196944 | 0.92 | CYP19A1 (0.86) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| Aminoglutethimide SCHEMBL27862969 | 0.88 | CYP19A1 (0.80) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| Aminoglutethimide SCHEMBL159173 | 0.87 | CYP19A1 (0.78) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111700878-A | Drug nanoparticles exhibiting enhanced mucosal transport | 卡拉制药公司 | 2020-09-25 | — | — | CN | disclosed |
| CN-111700880-A | Drug nanoparticles exhibiting enhanced mucosal transport | 卡拉制药公司 | 2020-09-25 | — | — | CN | disclosed |