Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.74 |
| ▸ | IKBKB | O14920 | 1/20 | 0.64 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.64 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | FLT4 | P35916 | 1/20 | 0.64 |
| ▸ | KDR | P35968 | 1/20 | 0.64 |
| ▸ | FRK | P42685 | 1/20 | 0.64 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.64 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.64 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.64 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.64 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.64 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.64 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.64 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.64 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.64 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28468370 | 0.95 | MAPK14 (0.67) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL28465714 | 0.93 | MAPK14 (0.73) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL4257752 | 0.85 | MAPK14 (1.00) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL4267810 | 0.84 | MAPK14 (0.86) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL4259053 | 0.84 | MAPK14 (0.88) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL28460408 | 0.81 | MAPK14 (0.76) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL31080012 | 0.80 | MAPK14 (0.90) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL4259120 | 0.80 | MAPK14 (0.90) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL31139613 | 0.80 | MAPK14 (0.84) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL4265451 | 0.80 | MAPK14 (0.84) | MAPK14IKBKBMAPK13PRKD3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114748622-A | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD | 弗尔康医疗公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-111601593-B | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2022-04-15 | — | — | CN | disclosed |
| CN-111601593-A | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2020-08-28 | — | — | CN | disclosed |