Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5234596 | 0.81 | SMN1; SMN2 (0.39) | MAPTPKMCYP1A2POLBALDH1A1 | |
| SCHEMBL5234603 | 0.81 | SMN1; SMN2 (0.39) | MAPTPKMCYP1A2POLBALDH1A1 | |
| SCHEMBL5237564 | 0.81 | SMN1; SMN2 (0.39) | MAPTPKMCYP1A2POLBALDH1A1 | |
| SCHEMBL21061153 | 0.81 | MAPT (0.40) | MAPTL3MBTL1POLBALDH1A1HTT | |
| SCHEMBL1810376 | 0.80 | HPGD (0.40) | MAPTPKMCYP1A2POLBALDH1A1 | |
| SCHEMBL1609142 | 0.77 | MAPT (0.61) | MAPTPKMCYP1A2POLBALDH1A1 | |
| SCHEMBL5414653 | 0.77 | POLB (0.41) | MAPTPOLBALDH1A1LMNAHTT | |
| SCHEMBL31735338 | 0.76 | HPGD (0.40) | MAPTL3MBTL1POLBALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11271192 | 0.76 | MAPT (0.59) | MAPTPKMCYP1A2POLBALDH1A1 | |
| SCHEMBL5416311 | 0.73 | MAPT (0.57) | MAPTL3MBTL1PKMPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111491936-A | Macrocyclic compounds as PDE1 inhibitors | H.隆德贝克有限公司 | 2020-08-04 | — | — | CN | disclosed |