Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 15/20 | 0.90 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | CAMK1D | Q8IU85 | 3/20 | 0.61 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.61 |
| ▸ | CSF1R | P07333 | 1/20 | 0.61 |
| ▸ | PIM1 | P11309 | 1/20 | 0.61 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | SYK | P43405 | 1/20 | 0.61 |
| ▸ | BLK | P51451 | 1/20 | 0.61 |
| ▸ | RIPK4 | P57078 | 1/20 | 0.61 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.61 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30568819 | 0.95 | IDH2 (1.00) | IDH2MAPTCAMK1DMAP3K7CSF1R | |
| SCHEMBL28456851 | 0.87 | IDH2 (0.89) | IDH2MAPTLMNA | |
| SCHEMBL28450626 | 0.86 | IDH2 (0.86) | IDH2MAPTLMNA | |
| SCHEMBL28451697 | 0.82 | IDH2 (1.00) | IDH2MAPT | |
| SCHEMBL30568829 | 0.82 | IDH2 (1.00) | IDH2MAPT | |
| SCHEMBL28460673 | 0.82 | IDH2 (1.00) | IDH2MAPT | |
| SCHEMBL30568801 | 0.82 | IDH2 (1.00) | IDH2MAPT | |
| SCHEMBL28451696 | 0.82 | IDH2 (1.00) | IDH2MAPT | |
| SCHEMBL30568818 | 0.82 | IDH2 (1.00) | IDH2MAPT | |
| SCHEMBL30568805 | 0.82 | IDH2 (1.00) | IDH2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111662242-B | Heterocyclic IDH mutant inhibitor, preparation method and application thereof | 中国药科大学 | 2023-10-24 | — | — | CN | disclosed |
| CN-111662242-A | Heterocyclic IDH mutant inhibitor, preparation method and application thereof | 中国药科大学 | 2020-09-15 | — | — | CN | disclosed |