Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 13/20 | 0.63 |
| ▸ | ACE | P12821 | 4/20 | 0.63 |
| ▸ | MMEL1 | Q495T6 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28460897 | 1.00 | MME (0.63) | MMEACEMMEL1 | |
| SCHEMBL21241439 | 1.00 | MME (0.63) | MMEACEMMEL1 | |
| SCHEMBL21221261 | 0.95 | MME (0.71) | MMEACEMMEL1 | |
| SCHEMBL21221260 | 0.95 | MME (0.71) | MMEACEMMEL1 | |
| SCHEMBL21221282 | 0.95 | MME (0.65) | MMEACEMMEL1 | |
| SCHEMBL21221283 | 0.95 | MME (0.65) | MMEACEMMEL1 | |
| SCHEMBL21221259 | 0.95 | MME (0.71) | MMEACEMMEL1 | |
| Sacubitril SCHEMBL8214132 | 0.90 | MME (0.77) | MMEACEMMEL1 | |
| Sacubitril SCHEMBL22420467 | 0.90 | MME (0.77) | MMEACEMMEL1 | |
| Sacubitril SCHEMBL2707112 | 0.90 | MME (0.77) | MMEACEMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111655671-A | Substituted bisphenyl butyrate derivatives as NEP inhibitors | 诺华股份有限公司 | 2020-09-11 | — | — | CN | claimed |
| CN-111655671-A | Substituted bisphenyl butyrate derivatives as NEP inhibitors | 诺华股份有限公司 | 2020-09-11 | — | — | CN | disclosed |