Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | FAP | Q12884 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.36 |
| ▸ | LAP3 | P28838 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28463120 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2SLC7A5CA14CA12DPP4 | |
| SCHEMBL135981 | 0.97 | — | — | |
| SCHEMBL135982 | 0.97 | — | — | |
| SCHEMBL204828 | 0.97 | — | — | |
| Ammonia Solution, Strong SCHEMBL27488505 | 0.95 | SMN1; SMN2 (0.48) | SMN1; SMN2SLC7A5CA14CA12DPP4 | |
| SCHEMBL2239379 | 0.95 | SMN1; SMN2 (0.48) | SMN1; SMN2SLC7A5CA14CA12DPP4 | |
| Hydrochloric Acid SCHEMBL203200 | 0.95 | SMN1; SMN2 (0.48) | SMN1; SMN2SLC7A5CA14CA12DPP4 | |
| Hydrochloric Acid SCHEMBL345942 | 0.95 | SMN1; SMN2 (0.48) | SMN1; SMN2SLC7A5CA14CA12DPP4 | |
| Hydrochloric Acid SCHEMBL261172 | 0.95 | SMN1; SMN2 (0.48) | SMN1; SMN2SLC7A5CA14CA12DPP4 | |
| Acetic Acid SCHEMBL28031091 | 0.90 | SLC7A5 (0.50) | SMN1; SMN2SLC7A5CA14CA12DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111763194-B | Preparation method of 2-bromothiophene | 浙江燎原药业股份有限公司 | 2021-09-21 | — | — | CN | disclosed |
| CN-111763194-A | Preparation method of 2-bromothiophene | 浙江燎原药业股份有限公司 | 2020-10-13 | — | — | CN | disclosed |