Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.62 |
| ▸ | IGF1R | P08069 | 6/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.62 |
| ▸ | FLT3 | P36888 | 3/20 | 0.61 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.61 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.61 |
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.51 |
| ▸ | CDK2 | P24941 | 4/20 | 0.51 |
| ▸ | TTK | P33981 | 1/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.49 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30956854 | 1.00 | EGFR (0.62) | EGFRIGF1RKCNH2FLT3MKNK1 | |
| SCHEMBL14719022 | 0.91 | EGFR (0.74) | EGFRIGF1RKCNH2FLT3MKNK1 | |
| SCHEMBL14663866 | 0.88 | EGFR (0.57) | EGFRIGF1RKCNH2FLT3MKNK1 | |
| SCHEMBL30108177 | 0.86 | FLT3 (0.60) | EGFRIGF1RKCNH2FLT3MKNK1 | |
| SCHEMBL14663301 | 0.86 | FLT3 (0.60) | EGFRIGF1RKCNH2FLT3MKNK1 | |
| SCHEMBL30956842 | 0.86 | ALK (0.57) | EGFRIGF1RKCNH2FLT3MKNK1 | |
| SCHEMBL29232072 | 0.86 | ALK (0.57) | EGFRIGF1RKCNH2FLT3MKNK1 | |
| SCHEMBL30956860 | 0.85 | ALK (0.68) | EGFRIGF1RKCNH2CDK2ALK | |
| SCHEMBL29232057 | 0.85 | ALK (0.68) | EGFRIGF1RKCNH2CDK2ALK | |
| SCHEMBL30998031 | 0.85 | EGFR (0.72) | EGFRIGF1RKCNH2FLT3MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115650974-B | N- [5- (pyrimidine-2-amino) -2, 4-disubstituted phenyl ] -cis-pentadiene amide derivative and application thereof | 天津大学 | 2024-06-18 | — | — | CN | disclosed |
| CN-108191861-B | N- [5- (pyrimidin-2-amino) -2, 4-disubstituted-phenyl ] -trans-2, 4-pentadiene-amide | 天津大学 | 2020-10-02 | — | — | CN | disclosed |