Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.76 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.64 |
| ▸ | TNF | P01375 | 6/20 | 0.64 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.64 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.64 |
| ▸ | HCK | P08631 | 3/20 | 0.64 |
| ▸ | ABL1 | P00519 | 2/20 | 0.64 |
| ▸ | RAF1 | P04049 | 2/20 | 0.64 |
| ▸ | LYN | P07948 | 2/20 | 0.64 |
| ▸ | SRC | P12931 | 2/20 | 0.64 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.64 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.64 |
| ▸ | CIT | O14578 | 1/20 | 0.64 |
| ▸ | MUSK | O15146 | 1/20 | 0.64 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.64 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.64 |
| ▸ | STK10 | O94804 | 1/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.64 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29593598 | 0.86 | MAPK14 (1.00) | MAPK14MAPK12TNFMAPK13MAPK11 | |
| SCHEMBL28468353 | 0.86 | MAPK14 (0.78) | MAPK14MAPK12TNFMAPK13MAPK11 | |
| SCHEMBL294394 | 0.86 | MAPK14 (1.00) | MAPK14MAPK12TNFMAPK13MAPK11 | |
| SCHEMBL295639 | 0.86 | MAPK14 (0.82) | MAPK14MAPK12TNFMAPK13MAPK11 | |
| SCHEMBL29593440 | 0.86 | MAPK14 (0.82) | MAPK14MAPK12TNFMAPK13MAPK11 | |
| SCHEMBL29593381 | 0.86 | MAPK14 (0.76) | MAPK14MAPK12TNFMAPK13MAPK11 | |
| SCHEMBL20876925 | 0.86 | MAPK14 (0.76) | MAPK14MAPK12TNFMAPK13MAPK11 | |
| SCHEMBL296487 | 0.86 | MAPK14 (0.76) | MAPK14MAPK12TNFMAPK13MAPK11 | |
| SCHEMBL30335874 | 0.83 | MAPK14 (0.65) | MAPK14MAPK12TNFMAPK13MAPK11 | |
| SCHEMBL295782 | 0.83 | MAPK14 (0.65) | MAPK14MAPK12TNFMAPK13MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114748622-B | P38 kinase inhibitors reduce DUX4 and downstream gene expression and treat FSHD | 弗尔康医疗公司 | 2024-09-24 | — | — | CN | disclosed |
| CN-114732910-B | P38 kinase inhibitors reduce DUX4 and downstream gene expression and treat FSHD | 弗尔康医疗公司 | 2024-08-23 | — | — | CN | disclosed |
| CN-114748622-A | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD | 弗尔康医疗公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-114732910-A | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2022-07-12 | — | — | CN | disclosed |
| CN-111601593-B | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2022-04-15 | — | — | CN | disclosed |
| CN-111601593-A | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2020-08-28 | — | — | CN | disclosed |