Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.73 |
| ▸ | JAK1 | P23458 | 14/20 | 0.73 |
| ▸ | JAK3 | P52333 | 3/20 | 0.48 |
| ▸ | CIT | O14578 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | ULK1 | O75385 | 1/20 | 0.47 |
| ▸ | PRKCB | P05771 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | PRKCA | P17252 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | MARK3 | P27448 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.47 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28468665 | 0.89 | JAK2 (0.58) | JAK2JAK1JAK3CITGAK | |
| SCHEMBL28462188 | 0.89 | JAK2 (0.58) | JAK2JAK1 | |
| SCHEMBL28462216 | 0.89 | JAK2 (0.58) | JAK2JAK1JAK3 | |
| SCHEMBL28462192 | 0.89 | JAK2 (0.58) | JAK2JAK1JAK3 | |
| SCHEMBL28461972 | 0.88 | JAK2 (0.57) | JAK2JAK1JAK3 | |
| SCHEMBL28465797 | 0.86 | JAK2 (0.56) | JAK2JAK1JAK3 | |
| SCHEMBL28468649 | 0.86 | JAK2 (0.56) | JAK2JAK1JAK3 | |
| SCHEMBL2394699 | 0.84 | JAK2 (1.00) | JAK2JAK1 | |
| SCHEMBL28459163 | 0.84 | JAK2 (0.53) | JAK2JAK1 | |
| SCHEMBL28462194 | 0.82 | JAK2 (0.66) | JAK2JAK1JAK3CITGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111620873-B | Pyrrolo [2,3-d ] pyrimidine derivatives containing piperidine and preparation and application thereof | 沈阳药科大学 | 2021-12-28 | — | — | CN | claimed |
| CN-111620873-A | Pyrrolo [2,3-d ] pyrimidine derivatives containing piperidine and preparation and application thereof | 沈阳药科大学 | 2020-09-04 | — | — | CN | claimed |
| CN-111620873-B | Pyrrolo [2,3-d ] pyrimidine derivatives containing piperidine and preparation and application thereof | 沈阳药科大学 | 2021-12-28 | — | — | CN | disclosed |
| CN-111620873-A | Pyrrolo [2,3-d ] pyrimidine derivatives containing piperidine and preparation and application thereof | 沈阳药科大学 | 2020-09-04 | — | — | CN | disclosed |