Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 19/20 | 0.44 |
| ▸ | CCND1 | P24385 | 17/20 | 0.44 |
| ▸ | CCND3 | P30281 | 14/20 | 0.44 |
| ▸ | CCND2 | P30279 | 9/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.44 |
| ▸ | CDK9 | P50750 | 4/20 | 0.44 |
| ▸ | CDK2 | P24941 | 8/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 8/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.43 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28468009 | 0.84 | CDK4 (0.42) | CDK4CCND1CCND3CCND2CCNT1 | |
| SCHEMBL4832697 | 0.82 | CDK4 (0.57) | CDK4CCND1CCND3CCND2CCNT1 | |
| SCHEMBL28467128 | 0.82 | CDK4 (0.54) | CDK4CCND1CCND3CCND2CCNT1 | |
| SCHEMBL19021358 | 0.81 | CDK4 (0.60) | CDK4CCND1CCND3CCND2CCNT1 | |
| SCHEMBL28463249 | 0.78 | CDK4 (0.45) | CDK4CCND1CCND3CCND2CCNT1 | |
| SCHEMBL6943376 | 0.74 | CDK4 (0.52) | CDK4CCND1CCND3CCND2CCNT1 | |
| SCHEMBL29507845 | 0.74 | CDK4 (0.52) | CDK4CCND1CCND3CCND2CCNT1 | |
| SCHEMBL4826130 | 0.74 | CDK4 (0.52) | CDK4CCND1CCND3CCND2CCNT1 | |
| SCHEMBL4825233 | 0.74 | CDK4 (0.52) | CDK4CCND1CCND3CCND2CCNT1 | |
| SCHEMBL1227553 | 0.74 | PIK3CA (0.44) | CDK4CCND1CCND3CCND2CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108191857-B | 6-substituted pyrido [2,3-D ] pyrimidines as protein kinase inhibitors | 晟科药业（江苏）有限公司 | 2020-10-23 | — | — | CN | disclosed |