Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.83 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.79 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.79 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.79 |
| ▸ | STRADA | Q7RTN6 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4382895 | 0.91 | MAPK14 (1.00) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL29594309 | 0.91 | MAPK14 (1.00) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL5862335 | 0.89 | MAPK14 (0.88) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL29593506 | 0.89 | MAPK14 (0.88) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL4384604 | 0.89 | MAPK14 (0.83) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| Ph-797804 SCHEMBL29351545 | 0.88 | MAPK14 (1.00) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| Ph-797804 SCHEMBL29527304 | 0.88 | MAPK14 (1.00) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| Ph-797804 SCHEMBL2015676 | 0.88 | MAPK14 (1.00) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL6506012 | 0.83 | MAPK14 (0.83) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL6473101 | 0.83 | MAPK14 (0.90) | MAPK14ROCK2MAPK12MAPK11STRADA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114748622-A | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD | 弗尔康医疗公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-114732910-A | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2022-07-12 | — | — | CN | disclosed |
| CN-111601593-B | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2022-04-15 | — | — | CN | disclosed |
| CN-111601593-A | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2020-08-28 | — | — | CN | disclosed |