Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sacubitril. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME known ✓ | P08473 | 12/20 | 0.63 |
| ▸ | ACE | P12821 | 4/20 | 0.63 |
| ▸ | MMEL1 | Q495T6 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sacubitril SCHEMBL29490800 | 1.00 | MME (0.63) | MMEACEMMEL1 | |
| Sacubitril SCHEMBL21239967 | 0.98 | MME (0.63) | MMEACEMMEL1 | |
| Sacubitril SCHEMBL21239966 | 0.98 | MME (0.63) | MMEACEMMEL1 | |
| Sacubitril SCHEMBL21239956 | 0.98 | MME (0.63) | MMEACEMMEL1 | |
| Sacubitril SCHEMBL29554043 | 0.98 | MME (0.63) | MMEACEMMEL1 | |
| Sacubitril SCHEMBL21239957 | 0.98 | MME (0.63) | MMEACEMMEL1 | |
| Sacubitril SCHEMBL18059569 | 0.90 | MME (0.77) | MMEACEMMEL1 | |
| Sacubitril SCHEMBL18059568 | 0.90 | MME (0.77) | MMEACEMMEL1 | |
| Sacubitril SCHEMBL1908525 | 0.90 | MME (0.77) | MMEACEMMEL1 | |
| Sacubitril SCHEMBL8214132 | 0.90 | MME (0.77) | MMEACEMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108373423-B | Preparation method of Sacubitril-valsartan compound and/or eutectic key intermediate Sacubitril calcium | 成都苑东生物制药股份有限公司 | 2020-10-23 | — | — | CN | disclosed |