Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.42 |
| ▸ | JAK3 | P52333 | 4/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | CCNK | O75909 | 2/20 | 0.32 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29489173 | 1.00 | JAK2 (0.42) | JAK2JAK3PDE4DMAPK3MEN1 | |
| SCHEMBL29489172 | 1.00 | JAK2 (0.42) | JAK2JAK3PDE4DMAPK3MEN1 | |
| SCHEMBL23084516 | 1.00 | JAK2 (0.42) | JAK2JAK3PDE4DMAPK3MEN1 | |
| SCHEMBL21098225 | 1.00 | JAK2 (0.42) | JAK2JAK3PDE4DMAPK3MEN1 | |
| SCHEMBL21098275 | 0.94 | JAK3 (0.41) | JAK2JAK3PDE4DMAPK3KMT2A | |
| SCHEMBL21098279 | 0.94 | JAK3 (0.41) | JAK2JAK3PDE4DMAPK3KMT2A | |
| SCHEMBL29489171 | 0.94 | JAK3 (0.41) | JAK2JAK3PDE4DMAPK3KMT2A | |
| SCHEMBL23084452 | 0.94 | JAK3 (0.41) | JAK2JAK3PDE4DMAPK3KMT2A | |
| SCHEMBL29489168 | 0.94 | JAK3 (0.41) | JAK2JAK3PDE4DMAPK3KMT2A | |
| SCHEMBL20851937 | 0.89 | JAK3 (0.40) | JAK2JAK3MAPK3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111712502-B | Substituted azetidine dihydro-thienopyrimidines and their use as phosphodiesterase inhibitors | 联合疗法公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-111712502-A | Substituted azetidine dihydrothienopyrimidines and their use as phosphodiesterase inhibitors | 利奥制药有限公司 | 2020-09-25 | — | — | CN | disclosed |