Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTPS1 | P17812 | 20/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21392166 | 0.79 | CTPS1 (0.44) | CTPS1 | |
| Hydrochloric Acid SCHEMBL21384603 | 0.78 | CTPS1 (0.43) | CTPS1 | |
| SCHEMBL21373839 | 0.78 | CTPS1 (0.49) | CTPS1 | |
| SCHEMBL25293825 | 0.76 | CTPS1 (0.51) | CTPS1 | |
| SCHEMBL21373873 | 0.76 | CTPS1 (0.50) | CTPS1 | |
| SCHEMBL22758466 | 0.76 | CTPS1 (0.48) | CTPS1 | |
| SCHEMBL28475048 | 0.75 | CTPS1 (0.53) | CTPS1 | |
| SCHEMBL21387613 | 0.75 | CTPS1 (0.44) | CTPS1 | |
| SCHEMBL22762569 | 0.74 | CTPS1 (0.47) | CTPS1 | |
| SCHEMBL28483022 | 0.74 | TRPV1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111868051-B | Aminopyrimidine derivatives as CTPS1 inhibitors | 斯泰普制药股份公司 | 2024-04-09 | — | — | CN | disclosed |
| CN-114008039-B | Compounds as human CTPS1 inhibitors for the treatment of proliferative diseases | 斯泰普制药股份公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-114008039-A | N- (5- (6-ethoxypyrazin-2-yl) pyridin-2-yl) -4- (2- (methylsulfonylamino) pyrimidin-4-yl) tetrahydro-2H-pyran-4-carboxamide derivatives and related compounds as human CTPS1 inhibitors for the treatment of proliferative diseases | 斯泰普制药股份公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-111868051-A | Aminopyrimidine derivatives as CTPS1 inhibitors | 斯泰普制药股份公司 | 2020-10-30 | — | — | CN | disclosed |