Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD38 | P28907 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.60 |
| ▸ | USP2 | O75604 | 3/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | EGFR | P00533 | 6/20 | 0.59 |
| ▸ | RAF1 | P04049 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27878333 | 0.88 | USP2 (0.65) | CD38LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL28469603 | 0.85 | MAPK1 (0.65) | CD38LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL28471823 | 0.85 | KDM4E (0.72) | CD38LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3007586 | 0.85 | ALK (0.72) | LMNAMEN1KMT2AALDH1A1EGFR | |
| SCHEMBL15587953 | 0.85 | CD38 (0.64) | CD38LMNACYP1A2CYP3A4CLK4 | |
| SCHEMBL29971755 | 0.85 | EGFR (0.70) | CD38LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1192879 | 0.85 | EGFR (0.70) | CD38LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5740246 | 0.85 | CNR1 (0.62) | CD38LMNAMEN1KMT2ATSHR | |
| SCHEMBL29058751 | 0.85 | EGFR (0.71) | CD38EGFRRAF1BRAFMAPK1 | |
| SCHEMBL30395473 | 0.85 | EGFR (0.71) | CD38EGFRRAF1BRAFMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107652275-B | Quinazoline derivative and preparation method and application thereof | 沈阳工业大学 | 2020-09-22 | — | — | CN | disclosed |