Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.55 |
| ▸ | NOS3 | P29474 | 2/20 | 0.47 |
| ▸ | NOS1 | P29475 | 2/20 | 0.47 |
| ▸ | NOS2 | P35228 | 2/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30591983 | 1.00 | DYRK1A (0.55) | DYRK1ANOS3NOS1NOS2MAPK10 | |
| SCHEMBL1224710 | 0.81 | DYRK1A (0.55) | DYRK1ANOS3NOS1NOS2CYP1A1 | |
| SCHEMBL7230871 | 0.81 | MAP4K4 (0.50) | ALOX5APPLAUMEN1KMT2AALDH1A1 | |
| SCHEMBL3361169 | 0.79 | DYRK1A (0.60) | DYRK1ANOS3NOS1NOS2MAPK10 | |
| SCHEMBL23956475 | 0.78 | DYRK1A (0.52) | DYRK1ANOS3NOS1NOS2CYP1A1 | |
| SCHEMBL3865219 | 0.78 | SYK (0.48) | ALOX5APPLAUPDGFRBPDGFRANSD2 | |
| SCHEMBL30592071 | 0.78 | CYP11B1 (0.55) | PLAUPDGFRBPDGFRAKDM4EMEN1 | |
| SCHEMBL12498949 | 0.78 | CYP11B1 (0.55) | PLAUPDGFRBPDGFRAKDM4EMEN1 | |
| SCHEMBL28480694 | 0.77 | DYRK1A (0.58) | DYRK1ANOS3NOS1NOS2MAPK10 | |
| SCHEMBL5702570 | 0.76 | CA1 (0.50) | PLAUPDGFRBPDGFRAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111936486-B | Heterocyclic compounds comprising pyridine as modulators of IL-12, IL-23 and/or IFN alpha responses | 百时美施贵宝公司 | 2023-09-22 | — | — | CN | disclosed |
| CN-111936486-A | Pyridine-containing heterocyclic compounds useful as modulators of IL-12, IL-23, and/or IFN alpha response | 百时美施贵宝公司 | 2020-11-13 | — | — | CN | disclosed |