Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.68 |
| ▸ | SHBG | P04278 | 2/20 | 0.68 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.60 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.60 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.60 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.60 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.59 |
| ▸ | AR | P10275 | 2/20 | 0.59 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.59 |
| ▸ | PGR | P06401 | 1/20 | 0.59 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29362020 | 1.00 | GPBAR1 (0.68) | GPBAR1LMNACYP3A4SHBGSERPINA6 | |
| SCHEMBL12178029 | 1.00 | GPBAR1 (0.68) | GPBAR1LMNACYP3A4SHBGSERPINA6 | |
| SCHEMBL12826007 | 1.00 | GPBAR1 (0.68) | GPBAR1LMNACYP3A4SHBGSERPINA6 | |
| SCHEMBL716358 | 1.00 | GPBAR1 (0.68) | GPBAR1LMNACYP3A4SHBGSERPINA6 | |
| SCHEMBL3366576 | 1.00 | GPBAR1 (0.68) | GPBAR1LMNACYP3A4SHBGSERPINA6 | |
| SCHEMBL24623303 | 1.00 | GPBAR1 (0.68) | GPBAR1LMNACYP3A4SHBGSERPINA6 | |
| SCHEMBL2593987 | 1.00 | GPBAR1 (0.68) | GPBAR1LMNACYP3A4SHBGSERPINA6 | |
| SCHEMBL19003336 | 1.00 | GPBAR1 (0.68) | GPBAR1LMNACYP3A4SHBGSERPINA6 | |
| SCHEMBL716359 | 1.00 | GPBAR1 (0.68) | GPBAR1LMNACYP3A4SHBGSERPINA6 | |
| SCHEMBL11469831 | 1.00 | GPBAR1 (0.68) | GPBAR1LMNACYP3A4SHBGSERPINA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904645-B1 | METHOD FOR PREDICTING AND MONITORING DIRECT RESPONSE TO CANCER THERAPY | SIEMENS HEALTHCARE DIAGNOSTICS (DE) | 2010-08-04 | — | — | EP | disclosed |
| EP-1436425-B1 | GENES AND PROTEINS FOR PREVENTION, PREDICTION, PROGNOSIS AND THERAPY OF CARDIOVASCULAR DISEASE | SIEMENS HEALTHCARE DIAGNOSTICS (DE) | 2009-12-02 | — | — | EP | disclosed |