Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 16/20 | 0.67 |
| ▸ | CDK2 | P24941 | 16/20 | 0.67 |
| ▸ | CDK9 | P50750 | 16/20 | 0.67 |
| ▸ | CDK1 | P06493 | 15/20 | 0.67 |
| ▸ | CCNB1 | P14635 | 15/20 | 0.67 |
| ▸ | CCNE1 | P24864 | 15/20 | 0.67 |
| ▸ | CDK7 | P50613 | 14/20 | 0.67 |
| ▸ | CCNH | P51946 | 14/20 | 0.67 |
| ▸ | CDK4 | P11802 | 12/20 | 0.67 |
| ▸ | CCND1 | P24385 | 12/20 | 0.67 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1531614 | 0.88 | CCNT1 (0.69) | CCNT1CDK2CDK9CDK1CCNB1 | |
| SCHEMBL11295188 | 0.84 | CDK2 (0.69) | CCNT1CDK2CDK9CDK1CCNB1 | |
| SCHEMBL1531501 | 0.81 | CCNT1 (0.54) | CCNT1CDK2CDK9CDK1CCNB1 | |
| SCHEMBL13373291 | 0.81 | CDK2 (0.65) | CCNT1CDK2CDK9CDK1CCNB1 | |
| SCHEMBL1531503 | 0.80 | CDK2 (1.00) | CCNT1CDK2CDK9CDK1CCNB1 | |
| SCHEMBL11942171 | 0.80 | CDK2 (0.49) | CCNT1CDK2CDK9CDK1CCNB1 | |
| SCHEMBL11300417 | 0.79 | CDK2 (0.75) | CCNT1CDK2CDK9CDK1CCNB1 | |
| SCHEMBL1531479 | 0.78 | CDK2 (1.00) | CCNT1CDK2CDK9CDK1CCNB1 | |
| SCHEMBL1532123 | 0.78 | CDK2 (0.71) | CCNT1CDK2CDK9CDK1CCNB1 | |
| SCHEMBL1531483 | 0.78 | CDK2 (0.57) | CCNT1CDK2CDK9CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641805-B1 | THIAZOLO-, OXAZALO AND IMIDAZOLO-QUINAZOLINE COMPOUNDS CAPABLE OF INHIBITING PROTEIN KINASES | CYCLACEL LTD (GB) | 2010-01-13 | — | — | EP | claimed |