SCHEMBL28483552

SCHEMBL28483552

Cc1c(C(=O)Nc2ccc(F)c(Cl)c2)c(Cl)n(C)c1C(=O)C(=O)NC(C)C(F)(F)F

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SLC10A1 Q14973 18/20 0.65
SMN1; SMN2 Q16637 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30361300 1.00 SLC10A1 (0.65) SLC10A1SMN1; SMN2
SCHEMBL21427908 1.00 SLC10A1 (0.65) SLC10A1SMN1; SMN2
SCHEMBL28484402 0.93 SLC10A1 (0.65) SLC10A1SMN1; SMN2
SCHEMBL21427878 0.93 SLC10A1 (0.65) SLC10A1SMN1; SMN2
SCHEMBL25645193 0.90 SLC10A1 (0.54) SLC10A1SMN1; SMN2
SCHEMBL21408333 0.88 SLC10A1 (0.52) SLC10A1
SCHEMBL21408330 0.88 SLC10A1 (0.52) SLC10A1
SCHEMBL30361254 0.88 SLC10A1 (0.52) SLC10A1
SCHEMBL21427863 0.88 SLC10A1 (0.52) SLC10A1
SCHEMBL22906129 0.83 SLC10A1 (0.54) SLC10A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115974753-A N-containing heterocyclic five-membered ring compound and application 正大天晴药业集团股份有限公司 2023-04-18 CN disclosed
CN-115974754-A N-containing heterocyclic five-membered ring compound and application 正大天晴药业集团股份有限公司 2023-04-18 CN disclosed
CN-111868026-A Capsid protein assembly inhibitor containing N-heterocyclic five-membered ring, pharmaceutical composition and application thereof 正大天晴药业集团股份有限公司 2020-10-30 CN disclosed