Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 17/20 | 0.76 |
| ▸ | INSR | P06213 | 14/20 | 0.76 |
| ▸ | IGF1R | P08069 | 14/20 | 0.76 |
| ▸ | EGFR | P00533 | 5/20 | 0.65 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.65 |
| ▸ | AURKA | O14965 | 2/20 | 0.65 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.65 |
| ▸ | JAK2 | O60674 | 2/20 | 0.65 |
| ▸ | STK10 | O94804 | 2/20 | 0.65 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.65 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.65 |
| ▸ | ABL1 | P00519 | 2/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.65 |
| ▸ | LCK | P06239 | 2/20 | 0.65 |
| ▸ | FYN | P06241 | 2/20 | 0.65 |
| ▸ | FES | P07332 | 2/20 | 0.65 |
| ▸ | CSF1R | P07333 | 2/20 | 0.65 |
| ▸ | YES1 | P07947 | 2/20 | 0.65 |
| ▸ | LYN | P07948 | 2/20 | 0.65 |
| ▸ | RET | P07949 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28479266 | 1.00 | ALK (0.76) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL19312802 | 0.89 | ALK (0.83) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL26087740 | 0.88 | ALK (0.86) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL30377906 | 0.88 | ALK (0.86) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL28479268 | 0.88 | ALK (0.79) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL26089861 | 0.87 | ALK (1.00) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL21235197 | 0.86 | ALK (0.73) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL19201792 | 0.86 | ALK (0.82) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL26090666 | 0.85 | ALK (0.79) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL15206735 | 0.84 | ALK (0.80) | ALKINSRIGF1REGFRCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112004809-A | 5-chloro-2, 4-pyrimidine derivatives as antitumor agents | 陆柯潮 | 2020-11-27 | — | — | CN | disclosed |