Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17647954 | 0.89 | SLC22A12 (0.37) | MAPTSLC22A12KMT2AALDH1A1HTT | |
| SCHEMBL17658947 | 0.86 | SLC22A12 (0.42) | TP53SLC22A12KMT2AMEN1ALDH1A1 | |
| SCHEMBL28483273 | 0.85 | SLC22A12 (0.41) | TP53SLC22A12KMT2AMEN1ALDH1A1 | |
| Lithium Ion SCHEMBL17648309 | 0.84 | SLC22A12 (0.38) | MAPTSLC22A12CYP11B1CYP11B2 | |
| SCHEMBL17647244 | 0.73 | MAPT (0.38) | MAPTTP53SLC22A12GAARAB9A | |
| SCHEMBL17649180 | 0.72 | PTGS1 (0.34) | — | |
| SCHEMBL17646963 | 0.71 | MAPT (0.48) | MAPTTP53SLC22A12GAARAB9A | |
| SCHEMBL2871405 | 0.68 | MAPK1 (0.53) | MAPTGAAALDH1A1LMNAKDM4E | |
| SCHEMBL17648044 | 0.67 | SLC22A12 (0.39) | MAPTSLC22A12KMT2AMEN1ALDH1A1 | |
| SCHEMBL17648305 | 0.66 | GRN (0.63) | MAPTSLC22A12GAAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107690281-B | Cystic fibrosis transmembrane transduction modulator modulators | 弗特克斯药品有限公司 | 2020-11-17 | — | — | CN | disclosed |