SCHEMBL28486236

SCHEMBL28486236

CC(F)(F)C1CC1C(=O)O

nearest known ligand 0.57

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 12/20 0.57
GRM3 Q14832 11/20 0.47
GABRR1 P24046 5/20 0.39
GABRR2 P28476 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28486235 1.00 GRM2 (0.57) GRM2GRM3GABRR1GABRR2
SCHEMBL22869499 1.00 GRM2 (0.57) GRM2GRM3GABRR1GABRR2
SCHEMBL23467404 1.00 GRM2 (0.57) GRM2GRM3GABRR1GABRR2
SCHEMBL22869500 1.00 GRM2 (0.57) GRM2GRM3GABRR1GABRR2
SCHEMBL21017003 0.80 GRM2 (0.50) GRM2GRM3GABRR1GABRR2
SCHEMBL24408704 0.80 GRM2 (0.50) GRM2GRM3GABRR1GABRR2
SCHEMBL24806528 0.80 GRM2 (0.50) GRM2GRM3GABRR1GABRR2
SCHEMBL937228 0.80 GRM2 (0.50) GRM2GRM3GABRR1GABRR2
SCHEMBL24806688 0.80 GRM2 (0.50) GRM2GRM3GABRR1GABRR2
SCHEMBL31332625 0.80 GRM2 (0.61) GRM2GRM3GABRR1GABRR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709708-A1 NOVEL CARBOXAMIDE DERIVATIVES ANGELINI PHARMA S.P.A. (IT) 2026-03-18 EP disclosed
WO-2024233603-A1 NOVEL CARBOXAMIDE DERIVATIVES ICAGEN, LLC (US) 2024-11-14 WO disclosed
CN-111819173-B CD73 inhibitors 伊莱利利公司 2023-06-06 CN disclosed
CN-111819173-A CD73 inhibitor 伊莱利利公司 2020-10-23 CN disclosed