SCHEMBL28487208

SCHEMBL28487208

CCOC(=O)C1=C(C)NC(=O)CC1c1ccccc1

nearest known ligand 0.70

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
GPBAR1 Q8TDU6 5/20 0.70
ADORA2B P29275 1/20 0.66
HTT P42858 1/20 0.59
DHFR P00374 1/20 0.57
TP53 P04637 4/20 0.57
ADORA3 P0DMS8 1/20 0.56
ALDH1A1 P00352 2/20 0.54
KDM4E B2RXH2 1/20 0.54
GAA P10253 1/20 0.54
HSD17B10 Q99714 1/20 0.54
TSHR P16473 1/20 0.54
CACNA1D Q01668 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17478238 0.88 GPBAR1 (0.89) GPBAR1HTTTP53
SCHEMBL880226 0.87 GPBAR1 (0.56) GPBAR1ADORA2BHTTDHFRTP53
SCHEMBL11778657 0.87 GPBAR1 (0.55) GPBAR1ADORA2BDHFRADORA3ALDH1A1
SCHEMBL30593827 0.87 GPBAR1 (0.75) GPBAR1ADORA2BHTTTP53ALDH1A1
SCHEMBL880375 0.86 HTT (0.78) GPBAR1HTTTP53ADORA3ALDH1A1
SCHEMBL8885844 0.85 CACNA1D (0.57) GPBAR1ADORA2BDHFRADORA3ALDH1A1
SCHEMBL17478043 0.83 GPBAR1 (1.00) GPBAR1HTTTP53ALDH1A1KDM4E
SCHEMBL16087933 0.81 CACNA1C (0.69) ADORA3TSHRCACNA1D
SCHEMBL16087932 0.81 CACNA1C (0.69) ADORA3TSHRCACNA1D
SCHEMBL17478107 0.81 GPBAR1 (1.00) GPBAR1HTTTP53ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106904710-B Application device of flocculating agent spiral pipeline 徐州工程学院 2020-12-18 CN disclosed