Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | MGLL | Q99685 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20949327 | 0.80 | GSK3B (0.72) | JAK3GSK3BDYRK1A | |
| SCHEMBL20948711 | 0.79 | GSK3B (0.58) | JAK3TSHRGSK3BDYRK1A | |
| SCHEMBL20950853 | 0.79 | GSK3B (0.58) | JAK3MGLLGSK3BDYRK1A | |
| SCHEMBL20950462 | 0.78 | GSK3B (0.72) | JAK3GSK3BDYRK1A | |
| SCHEMBL20949724 | 0.78 | DYRK1A (0.72) | GSK3BDYRK1A | |
| SCHEMBL20950190 | 0.78 | DYRK1A (0.72) | JAK3GSK3BDYRK1A | |
| SCHEMBL20949883 | 0.77 | GSK3B (0.59) | JAK3GSK3BDYRK1A | |
| SCHEMBL20947437 | 0.77 | GSK3B (0.72) | SMN1; SMN2GSK3BDYRK1A | |
| SCHEMBL20966864 | 0.77 | GSK3B (0.47) | JAK3TSHRGSK3BDYRK1A | |
| SCHEMBL20949402 | 0.77 | GSK3B (0.72) | GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111973602-B | Application of morpholinyl acetamido quinazoline compound as EGFR (epidermal growth factor receptor) inhibitor | 浙江工业大学 | 2022-02-11 | — | — | CN | disclosed |
| CN-111973602-A | Application of morpholinyl acetamido quinazoline compound as EGFR (epidermal growth factor receptor) inhibitor | 浙江工业大学 | 2020-11-24 | — | — | CN | disclosed |