Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 6/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.51 |
| ▸ | SYK | P43405 | 2/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.51 |
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | INSR | P06213 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16343564 | 0.83 | GSK3B (0.61) | AXLNTRK1CHEK1DYRK1AGSK3B | |
| SCHEMBL28485422 | 0.82 | PARP1 (0.52) | AXLNTRK1CHEK1SYKDYRK1A | |
| SCHEMBL4448012 | 0.80 | AXL (0.58) | AXLNTRK1CHEK1SYKDYRK1A | |
| SCHEMBL20585262 | 0.80 | MAP3K11 (0.50) | AXLNTRK1CHEK1SYKDYRK1A | |
| SCHEMBL20584650 | 0.80 | AXL (0.71) | AXLNTRK1CHEK1SYKDYRK1A | |
| SCHEMBL18615789 | 0.79 | PRKCI (0.56) | AXLCHEK1SYKPRKCIMERTK | |
| SCHEMBL2354760 | 0.79 | CYP2C19 (0.49) | EGFRKDRNEK2 | |
| SCHEMBL28912619 | 0.76 | CHEK1 (0.63) | CHEK1MAP3K11 | |
| SCHEMBL20585269 | 0.75 | CHEK1 (0.64) | CHEK1MAP3K11 | |
| SCHEMBL14655483 | 0.74 | ATR (0.44) | NTRK1SYKABL1PIM1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106866658-B | 1H-pyrrolo [2,3-b ] pyridine derivatives and their use as kinase inhibitors | 沃纳利斯(R&D)有限公司 | 2021-04-27 | — | — | CN | disclosed |
| CN-111484493-A | 1H-pyrrolo [2,3-b ] pyridine derivatives and their use as kinase inhibitors | 沃纳利斯(R&D)有限公司 | 2020-08-04 | — | — | CN | disclosed |