Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 20/20 | 0.57 |
| ▸ | CDK6 | Q00534 | 17/20 | 0.57 |
| ▸ | CDK2 | P24941 | 13/20 | 0.57 |
| ▸ | CDK1 | P06493 | 7/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.57 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.57 |
| ▸ | CCND1 | P24385 | 4/20 | 0.56 |
| ▸ | CCND3 | P30281 | 4/20 | 0.56 |
| ▸ | CDK9 | P50750 | 4/20 | 0.55 |
| ▸ | CDK7 | P50613 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19967988 | 0.95 | CDK4 (0.58) | CDK4CDK6CDK2CDK1CCNB1 | |
| SCHEMBL19968021 | 0.90 | CDK4 (0.58) | CDK4CDK6CDK2CDK1CCNB1 | |
| SCHEMBL19966597 | 0.90 | CDK4 (0.45) | CDK4CDK6CDK2CDK1CCNB1 | |
| SCHEMBL19968042 | 0.89 | CDK4 (0.60) | CDK4CDK6CDK2CDK1CCNB1 | |
| SCHEMBL19967981 | 0.88 | CDK4 (0.58) | CDK4CDK6CDK2CDK1CCNB1 | |
| SCHEMBL29405522 | 0.88 | CDK4 (0.58) | CDK4CDK6CDK2CDK1CCNB1 | |
| SCHEMBL19967982 | 0.87 | CDK4 (0.60) | CDK4CDK6CDK2CDK1CCNB1 | |
| SCHEMBL19968031 | 0.86 | CDK4 (0.61) | CDK4CDK6CDK2CDK1CCNB1 | |
| SCHEMBL19968045 | 0.86 | CDK4 (0.61) | CDK4CDK6CDK2CDK1CCNB1 | |
| SCHEMBL30926189 | 0.86 | CDK4 (0.61) | CDK4CDK6CDK2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112225724-B | Benzimidazole compound kinase inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2022-04-29 | — | — | CN | disclosed |
| CN-112250669-B | Benzimidazole compound kinase inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2022-02-25 | — | — | CN | disclosed |
| CN-112250669-A | Benzimidazole compound kinase inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2021-01-22 | — | — | CN | disclosed |
| CN-112225724-A | Benzimidazole compound kinase inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2021-01-15 | — | — | CN | disclosed |
| CN-109963842-B | Benzimidazole compound kinase inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2020-11-03 | — | — | CN | disclosed |