Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 15/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 15/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | LTK | P29376 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | PRKX | P51817 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27698209 | 0.83 | IKBKB (0.61) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL28491887 | 0.81 | ADORA2A (0.56) | ADORA2AADORA1ADORA2B | |
| SCHEMBL28505779 | 0.81 | ADORA2A (0.62) | ADORA2AADORA1ADORA2B | |
| SCHEMBL28491044 | 0.81 | ADORA2A (0.59) | ADORA2AADORA1ADORA2B | |
| SCHEMBL28497643 | 0.81 | ADORA2A (0.52) | ADORA2AADORA1ADORA2B | |
| SCHEMBL28905138 | 0.78 | ADORA2A (0.58) | ADORA2AADORA1ADORA2B | |
| SCHEMBL28505688 | 0.78 | ADORA2A (0.52) | ADORA2AADORA1ADORA2B | |
| SCHEMBL28493942 | 0.78 | ADORA1 (0.58) | ADORA2AADORA1ADORA2B | |
| SCHEMBL28494952 | 0.78 | ADORA2A (0.51) | ADORA2AADORA1ADORA2B | |
| SCHEMBL28501161 | 0.77 | ADORA2A (0.52) | ADORA2AADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108467386-B | Fused heteroaryl substituted 1,2, 4-triazine-3-amine derivatives, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2020-11-17 | — | — | CN | disclosed |