Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 20/20 | 0.50 |
| ▸ | NTRK3 | Q16288 | 11/20 | 0.50 |
| ▸ | NTRK2 | Q16620 | 9/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29088918 | 0.85 | NTRK1 (0.52) | NTRK1NTRK3NTRK2 | |
| SCHEMBL29766708 | 0.85 | NTRK1 (0.61) | NTRK1NTRK3NTRK2 | |
| SCHEMBL29088921 | 0.84 | NTRK1 (0.49) | NTRK1NTRK3NTRK2 | |
| SCHEMBL23070830 | 0.82 | NTRK1 (0.52) | NTRK1NTRK3NTRK2 | |
| SCHEMBL23070828 | 0.82 | NTRK1 (0.52) | NTRK1NTRK3NTRK2 | |
| SCHEMBL29088981 | 0.81 | NTRK1 (0.47) | NTRK1NTRK3NTRK2 | |
| SCHEMBL29088919 | 0.81 | NTRK1 (0.47) | NTRK1NTRK3NTRK2 | |
| SCHEMBL28491933 | 0.79 | NTRK1 (0.54) | NTRK1NTRK3NTRK2 | |
| SCHEMBL24503108 | 0.75 | NTRK1 (0.54) | NTRK1NTRK3NTRK2 | |
| SCHEMBL27060221 | 0.75 | NTRK1 (0.54) | NTRK1NTRK3NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111918868-A | Diaryl macrocycles as protein kinase modulators | 正大天晴药业集团股份有限公司 | 2020-11-10 | — | — | CN | disclosed |