Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.49 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | F13A1 | P00488 | 2/20 | 0.39 |
| ▸ | TGM2 | P21980 | 2/20 | 0.39 |
| ▸ | TGM1 | P22735 | 2/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29782450 | 1.00 | BTK (0.49) | BTKENPP2USP30NPC1RAB9A | |
| SCHEMBL17707882 | 1.00 | BTK (0.49) | BTKENPP2USP30NPC1RAB9A | |
| SCHEMBL17699685 | 0.85 | BTK (0.58) | BTK | |
| SCHEMBL28492343 | 0.85 | BTK (0.58) | BTK | |
| SCHEMBL17707884 | 0.83 | BTK (0.53) | BTKNPC1RAB9ASMN1; SMN2PGR | |
| SCHEMBL29782615 | 0.83 | BTK (0.53) | BTKNPC1RAB9ASMN1; SMN2PGR | |
| SCHEMBL28905210 | 0.83 | BTK (0.53) | BTKNPC1RAB9ASMN1; SMN2PGR | |
| SCHEMBL20863093 | 0.77 | BTK (0.54) | BTKCTSLCTSBCTSK | |
| SCHEMBL17707905 | 0.77 | BTK (0.54) | BTKCTSLCTSBCTSK | |
| SCHEMBL29782655 | 0.77 | BTK (0.54) | BTKCTSLCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110511209-B | Indole carboxamide compounds useful as kinase inhibitors | 百时美施贵宝公司 | 2022-07-05 | — | — | CN | disclosed |
| CN-107108583-B | Indole carboxamide compounds useful as kinase inhibitors | 百时美施贵宝公司 | 2020-11-13 | — | — | CN | disclosed |